Toussaint BW, et al. - Authors evaluated the intravitreal aflibercept injection (IAI) in subjects with presumed ocular histoplasmosis syndrome and choroidal neovascularization. The average age of the patients was 50 years (19–75). Overall average visual acuity at baseline was 68 letters with Snellen equivalent of 20/42. Sustained Group's average visual acuity was 84.9 letters and Snellen equivalent was 20/21 at 12-month follow-up, suggesting an average improvement of 12 letters (6 letters loss to 36 letters gain). It was noted intravitreal aflibercept to improve the visual and anatomical outcomes with a favorable safety profile. Compared with sustained dosing, PRN IAI dosing required fewer injections with similar visual and anatomical outcomes.