Edward JA, et al. - Whether reversal of regadenoson with aminophylline is safe and equal to adenosine for fractional flow reserve (FFR) measurements was investigated in 46 consecutive patients who underwent clinically indicated FFRs at the time of coronary angiography. Using adenosine 140 mcg/kg/min IV, FFR was measured in each patient. After return to baseline, FFR was measured using regadenoson 400 mcg IV, which then was reversed with aminophylline 150 mg IV. They measured time to baseline hemodynamics. Using linear regression, they compared agreement between the two assessments. According to findings, regadenoson and adenosine were equal hyperemic agents for FFR measurement. Hemodynamics took 111±71 seconds to return to baseline following aminophylline reversal of regadenoson. No unexpected side effects or complications were reported. Regadenoson with aminophylline reversal could serve as an alternative to adenosine for FFR measurements.