Silvain J, Kerneis M, Zeitouni M, et al. - Among patients with acute ST-segment elevation myocardial infarction (MI) who received primary percutaneous coronary intervention, this inquiry was performed to examine the link between interleukin (IL)-1β level with all-cause death and the interplay between IL-1β and high-sensitivity C-reactive protein (hs-CRP) levels on the risk of premature mortality. A prospective cohort with 1,398 patients with ST-segment elevation MI was used. Major adverse cardiovascular events (MACEs) were evaluated. A link of admission IL-1β level with all-cause mortality at 90 days was identified. The association was nonlinear, and higher death rates at 90 days and at 1 year were noted in relation to the highest tertile of IL-1β, irrespective of the hs-CRP level. Overall, findings revealed that IL-1β assessed at admission was independently related to the risk of death and recurrent MACEs in patients suffering from acute MI.

IL-1β measured at admission in patients with acute MI was independently associated with the risk of mortality and recurrent MACEs.