Lin HY, et al. - In African American (AA) men, researchers studied single nucleotide polymorphism (SNP)-SNP interactions in the CASC11-MYC-PVT1 region related to prostate cancer (PCa) risk. In 2,253 PCa patients and 2,423 controls, they used multi-phase (discovery-validation) design and assessed 205 SNPs. They also used the SNP Interaction Pattern Identifier (SIPI) to assess SNP-SNP interactions, in addition to SNP individual impact. PCa risk had a significant association with three SNPs (rs9642880, rs16902359, and rs12680047) and 79 SNP-SNP pairs, and a new interaction of CASC11-PVT1, which was the most common of the gene interactions (70%) in the top 79 pairs, was identified. Overall, findings highlighted a larger influence of novel SNP-SNP interactions in the CASC11-MYC-PVT1 region vs SNP individual effects on PCa risk in AA men.