Grauslund J, et al. - Utilizing national register‐based data in the Danish Excellence Centre in Ophthalmic Epidemiology (DECODE‐EYE), researchers sought to analyze interactions between ocular and systemic disease. Denmark has a strong tradition of registered health research, given the high number of validated national registers and databases. DECODE‐EYE will provide large-scale Danish data on associations between ocular and systemic diseases. With a target population of 5.8 million people, 12 separate studies (Protocols A–L) were initially designed to be studied in the coming years. These will provide novel data on interactions between systemic disease and relevant ophthalmological endpoints such as blindness, DR, glaucoma, corneal disease, retinal vascular disease, cataract and intravitreal angiostatic therapy.