Johnston KC, et al. - Via a randomized clinical trial with 1,151 adults who on either intensive treatment of hyperglycemia (target blood glucose concentration of 80-130 mg/dL) or standard treatment of hyperglycemia (target glucose concentration of 80-179 mg/dL), researchers assessed if intensive glucose control impacted functional outcome in patients with hyperglycemic acute ischemic stroke. Only 1,118 out of the initial 1,151 completed the trial. The mean blood glucose level in the intensive treatment group and in the standard treatment group was 118 mg/dL and 179 mg/dL, respectively, during treatment. In 119 of 581 patients in the intensive treatment group and in 123 of 570 patients in the standard treatment group, a positive outcome was seen. Due to hypoglycemia or other adverse events, treatment was discontinued early in 65 of 581 and 18 of 570 subjects in the intensive and standard treatment groups, respectively. Only among subjects in the intensive treatment group was severe hypoglycemia seen. Treatment with intensive vs standard glucose control for up to 72 hours did not lead to an important variation in favorable functional outcome at 90 days in subjects with acute ischemic stroke and hyperglycemia. In this setting, intensive glucose control is not recommended.