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Intensive Blood Pressure Reduction in Deep Intracerebral Hemorrhage

JAMA Neurology May 16, 2019

Leasure AC, et al. – In patients with deep intracerebral hemorrhage, researchers assessed if the risk of hematoma expansion is lowered and outcomes improved with intensive blood pressure reduction. This exploratory analysis of the Antihypertensive Treatment of Acute Cerebral Hemorrhage–2 international, multicenter randomized clinical trial included 870 (87.0%) trial participants with deep ICH, of whom 780 (89.7%) had complete neuroimaging data. Intensive blood pressure treatment vs standard treatment was related to reduced hematoma expansion in deep ICH, especially in basal ganglia hemorrhages. Improvement in the modified Rankin Scale score distribution was not linked to intensive treatment.

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