Kim Y, et al. - By performing a systematic review and meta-analysis of prospective studies, researchers examined the link between n-3 polyunsaturated fatty acids (PUFAs) and colorectal cancer. They explored PubMed and Embase databases through July 10, 2019, as well as performed a manual search, to identify the relevant studies. This analysis included 20 prospective studies with 18,102 cases and 1,360,046 participants. For the highest vs lowest category of n-3 PUFA consumption, the pooled RR of colorectal cancer was 0.97 (95% CI: 0.90-1.04). Concerning n-3 PUFA type, inverse links of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) consumptions with 11% and 12% lower colorectal cancer risks, respectively, were revealed in the comparison of the highest vs lowest category. Lower colorectal cancer risk was observed in relation to increases of 0.1 g/day of EPA and DHA intakes. Overall, findings revealed an inverse link of high blood n-3 PUFA levels with colorectal cancer risk, as well as a suggestive link of high n-3 PUFA consumption with lower colorectal cancer risk.