Wang Q, Jokelainen J, Auvinen J, et al. - In this first population-based large-scale metabolomics time-series study, researchers comprehensively described systemic metabolic responses to oral glucose in large scale and examined whether insulin resistance was correlated with postprandial metabolic dysregulation across multiple clinical categories of glucose intolerance. They conducted an oral glucose tolerance test (OGTT) across four-time points and quantified 78 metabolic measures for a total of 5,340 people (over 21,000 serum samples) from two independent population-based cohorts. They obtained blood samples at 0 (fasting baseline, right before glucose ingestion), 30, 60, and 120 min during the OGTT. Patients had a 2-h, 75-g OGTT after overnight fasting. Ingestion of glucose caused several metabolic responses, including increased intermediate glycolysis and reduced branched-chain amino acids, ketone bodies, glycerol, and triglycerides. According to findings, non-diabetic insulin-resistant individuals are exposed to a comparable adverse postprandial metabolic milieu and cardiometabolic risk compared with that of type 2 diabetes people. The wide range of IR-related metabolic disorders highlights the need for diabetes diagnosis and clinical care beyond glucose control.