Patel BK, et al. - Researchers reported their experience using tomosynthesis-guided vacuum-assisted biopsies (VABs) for architectural distortion (AD) that were occult at 2D mammography and ultrasound and analyzed the positive predictive value for malignancy. They identified tomosynthesis-guided VAB as a feasible method to sample ADs that are occult at 2D mammography and ultrasound. Tomosynthesis-guided VAB is a minimally invasive method. It detected a significant number of carcinomas, most of which were grade 1 cancers.