Frati G, Forte M, di Nonno F, et al. - Researchers investigated the acute impacts of tobacco cigarette smoking on endothelial cell‐related circulating microRNAs (endogenous, small noncoding RNAs involved in the regulation of gene expression) in healthy people. Also, they sought to determine the potential role of microRNAs in smoking‐dependent endothelial cell damage. In healthy persons, experts quantified a panel of endothelial‐related microRNAs prior to and following smoking 1 tobacco cigarette. Shortly post-smoking, a significant rise in serum levels of miR‐155 was detected. In addition to enhancing oxidative stress, cigarette smoke condensate seemed to impair cell survival, angiogenesis, and NO metabolism in human endothelial cells. Notably, miR‐155 inhibition abrogated these impacts. Overall, experts concluded a likely contribution of miR‐155 dysregulation to the deleterious vascular impacts of tobacco smoking.