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Inhaled corticosteroids, blood eosinophils, and FEV1 decline in patients with COPD in a large UK primary health care setting

International Journal of COPD May 31, 2019

Whittaker HR, et al. - Researchers determined if differences could be seen in FEV1 decline between patients with and without inhaled corticosteroid (ICS), stratified by blood eosinophil (EOS) level. Participants included COPD patients (aged 35 years or older) who were current or ex-smokers with ≥2 FEV1 measurements ≥6 months apart. These subjects were selected from the UK Clinical Practice Research Datalink (primary care records) and Hospital Episode Statistics (hospital records). According to the findings, a link was evident between prevalent ICS use and slower rates of FEV1 decline in COPD, irrespective of blood EOS level.
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