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Influence of mortality on estimating the risk of kidney failure in people with stage 4 chronic kidney disease

Journal of the American Society of Nephrology Sep 29, 2019

Ravani P, Fiocco M, Liu P, et al. - As most kidney failure risk calculators depend on methods that censor for death, but the risk of kidney failure in individuals with severe, nondialysis-dependent CKD may be overestimated by censoring for death because of high mortality in these people, therefore, researchers held this inquiry among adults with stage 4 CKD in Alberta, Canada, to analyze the time to the earliest of kidney failure, death, or censoring, employing methods that censor for death and methods that use death as a competing event factoring in age, sex, diabetes, cardiovascular disease, eGFR, and albuminuria. At 5 years and at 7.5 years, the risk of the combined endpoint of death or kidney failure was estimated to be 64% and 87%, respectively. By comparison, these risks were estimated to be 76% and > 100% at 5 years and at 7.5 years, respectively, when standard risk calculators that censored for death were used. Experts concluded that, in order to increase the accuracy as well as the utility of kidney failure risk calculators, these tools should account for death as a competing risk.
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