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Influence of body mass index on recurrence of ventricular arrhythmia, mortality in defibrillator recipients with ischaemic cardiomyopathy

Heart, Lung, and Circulation Feb 03, 2019

Samanta R, et al. - Among 123 consecutive patients with ischemic cardiomyopathy (left ventricular ejection fraction (LVEF) ≤ 40%) and a primary or secondary prevention defibrillator, researchers investigated the influence of body mass index (BMI) on the recurrence of ventricular arrhythmia (VA) and mortality. Normal (18.5–24.99, n = 54/ 43.9%), overweight (2 –29.99, n = 43/ 35%) or obese (>30, n = 26/20.3%) categories of patients were defined based on BMI status. In 36%, 5.4% and 11.5% of patients with normal, overweight and obese BMI, respectively, the the primary combined outcome (VA recurrence and mortality) was reported. BMI was identified as a significant predictor for the combined primary outcome of spontaneously occurring ventricular arrhythmias and mortality in defibrillator recipients with ischemic cardiomyopathy. Worse outcomes were observed among patients with normal BMI vs those with overweight and obese status. This was suggestive of the presence of the obesity paradox in ventricular arrhythmogenesis late post-infarction.

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