Wongpraparut N, Pengchata P, Piyophirapong S, et al. - The present study was conducted to evaluate whether indoleamine 2,3 dioxygenase (IDO) level is a marker for significant coronary artery disease. Patients who were scheduled to undergo coronary angiography were prospectively enrolled. Researchers conducted measurement of IDO, high-sensitivity troponin T (hs-TnT), high-sensitivity C-reactive protein levels at baseline, and IDO activity was monitored at the 6-month follow-up. The study included a total of 305 patients. The results demonstrate that immunometabolic response mediated via IDO function was enhanced in patients with coronary artery disease, and associated with the extent and severity of the disease. As per the findings, patients with LM disease had higher 1-year mortality. The outcomes suggested that lower levels of IDO, as implied by inadequate IDO response, indicated a trend toward predicting 1-year mortality.