Kim HL, et al. - In the present study, laboratory findings and tumor necrosis factor-alpha (TNF-α) levels of scrub typhus patients were examined to determine the prognostic predictors of disease severity. Patients with confirmed scrub typhus diagnosis were classified according to disease severity into one of three groups; ie, deceased (n = 7), severe (n = 15), and mild (n = 15) retrospectively registered. These groups exhibited the mean TNF-α levels of 53.5 (range: 7.8–147.8), 26.0 (1.7–64.4), and 8.8 pg/mL (4.6–16.0), respectively. These findings suggest a possible predictive value of an elevated serum TNF-α level for a severe condition or death in these patients and for patient prognosis.