Sperry BW, Saeed IM, Raza S, et al. - Given the increasing recognization of cardiac amyloidosis as a cause of heart failure with preserved or mildly reduced ejection fraction with emerging treatment options, researchers examined the temporal trends and impact of hospital admissions in patients with amyloidosis. Querying the National Inpatient Sample from 2005 to 2014, they identified a total of 156,914 admissions in patients with amyloidosis (age 69.86 +/− 12.33 years, 45.7% female, 68.5% Caucasian). The analysis revealed that in 2014, hospitalizations more than doubled with a peak of 21,740 per year and 62 per 100,000 admissions. Over time, more frequent admission with amyloidosis was observed for patients who were older and had co-morbid medical conditions. A diagnosis of heart failure was reported in 34.7% of patients, rose over time, and was connected with further morbidity and mortality. A propensity-matched analysis revealed that patients admitted with amyloidosis had a longer length of stay (7.5 vs 6.2 days), were less frequently discharged home (43.6% vs 48.7%), and had more frequently died during the hospitalization (7.4% vs 4.9%).