Christiansen AL, et al. - In this investigation, researchers compared all-cause and cause-specific mortality between a nationwide cohort of patients with porphyria cutanea tarda (PCT) and a matched population sample. All Danish patients diagnosed with PCT from 1989-2012 were included. Data reported that the 20-year survival was 42.9% for patients with PCT vs 60.5% for matched controls. The cause-specific mortality for non-malignant gastrointestinal diseases and cancers of the gut, liver/gallbladder, and lungs have been significantly increased. Overall, the authors concluded that PCT patients have increased mortality, primarily due to increased mortality from gastrointestinal diseases and gut, liver/gallbladder, and lung cancers.