Gebhard C, Maredziak M, Messerli M, et al. - Given there exist significant gender-specific differences in left ventricular ejection fraction (LVEF), with a higher LVEF being noted in women, researchers evaluated the clinical significance of an elevated LVEF in women and men. For this purpose, they used the CONFIRM registry, and selected 4,632 patients. They found a high prevalence of increased LVEF in patients referred for assessment of coronary artery disease (CAD). An increased risk of mortality in women, but not in men, was observed in relation to increased LVEF. Improved risk stratification in women with CAD might be achieved by distinguishing between normal and hyperdynamic left ventricles.