Iwase M, Komorita Y, Fujii H, et al. - In Japanese patients with type 1 or insulin‐treated type 2 diabetes, researchers sought to prospectively examine the incidence of severe hypoglycemia, defined as events requiring the assistance of others for recovery from hypoglycemia, and its risk factors including an insulin‐sensitizing adipokine, adiponectin. In total, 207 candidates with type 1 diabetes (mean age 55 years) and 1,396 with insulin‐treated type 2 diabetes (mean age 65 years) from the local diabetes registry have been followed for 5 years (follow‐up rate 99%). Data reported that severe hypoglycemia incidence was 9.2 per 100 person‐years for those with type 1 diabetes, and 2.3 per 100 person‐years for those with insulin‐treated type 2 diabetes, respectively. The risk for insulin‐treated type 2 diabetes included age ≥ 65 years, history of severe hypoglycemia within the previous year, alcohol intake ≥ 60 g/day, larger insulin dose and higher serum adiponectin. The incidence of severe hypoglycemia increased along with serum adiponectin for all participants. The incidence of severe hypoglycemia was prospectively assessed, and in Japanese patients with type 1 and insulin‐treated type 2 diabetes, the correlation between severe hypoglycemia and higher serum adiponectin was noted.