Cordtz RL, et al. - This study entailed estimation of the incidence of total hip (THR) and knee replacements (TKR) in Denmark following the introduction of biological disease-modifying anti-rheumatic drugs (bDMARDs) and associated rheumatoid arthritis (RA) management guidelines. Three-fold and 14-fold higher incidence rate of THR and TKR, respectively, was reported among patients with RA when compared with general population comparators (GPCs) in 1996. A declining incidence rate of TKR was noted in RA patients in association with the introduction of bDMARDs, whereas, the incidence of THR had started to decrease before bDMARD introduction.