Dutheil C, Le Goff M, Cougnard-Grégoire A, et al. - Among individuals 77 years of age or older, researchers sought to identify the occurrence of reticular pseudodrusen (RPD) using retinal color photographs, spectral-domain optical coherence tomography scans, fundus autofluorescence, and near-infrared reflectance images and to examine the related risk factors of RPD. Data for this analysis were obtained between February 22, 2011, and February 15, 2017, with a mean (SD) follow-up of 3.7 (1.0) years (range, 1.2-5.6 years). The authors discovered an annual incidence of reticular pseudodrusen per participant of 2.9% and an estimated 5-year incidence of 13.5%. Age, choroidal thinning, and genetic background were found to be correlated with incident reticular pseudodrusen, while lipophilic statin therapy was related to a lower risk. Using of multimodal imaging, the incidence rate of RPD was higher than previously reported in other population-based studies utilizing fundus color images. People with subfoveal choroidal thinning or carrying minor allelic variants for ARMS2, CFH, or LIPC had an elevated risk for RPD, while lipophilic statin therapy was linked to a lower incidence.