Li EY, et al. - Via a model-based comparison study, researchers contrasted the current WHO guideline-based approaches from 2012 to an alternative, adaptive decision-making framework for control in heterogeneous environments, to evaluate their predicted relative efficiency and time to attainment of defined public health goals. In high-risk communities, current WHO strategies for MDA were not prognosticated to attain morbidity control in 80% of simulations over a 10-year period, whereas the modified adaptive approach was prognosticated to accomplish this goal in over 50% of simulations within 5 years. In low-risk and moderate-risk communities, current WHO guidelines from 2012 were prognosticated to attain morbidity control in most simulations, however, the suggested adaptive approach attained this goal in a shorter period. The model prognosticated that adding snail control to the proposed adaptive strategy would accomplish morbidity control in all high-risk communities, and 54% of communities could grasp the goal for elimination as a public health problem (< 1% heavy infection) within 7 years. Therefore, the modified adaptive decision-making framework is prognosticated to be more efficient compared with the current WHO guidelines in reaching 2025 public health goals, particularly for high-prevalence regions. Changes in current guidelines could decrease the time and resources required for countries that are currently managing to attain public health goals, against schistosomiasis.