Lévesque V, Laplante L, Shohoudi A, et al. - Researchers undertook an international cross-sectional study to evaluate as well as compare patient-reported outcomes (PROs) among adults with congenital heart disease (CHD) with and without implantable cardioverter-defibrillators (ICDs). Adults with CHD were recruited from 15 countries across 5 continents. Overall patients were 3,188 in total, including 107 with ICDs and 3,081 weight-matched controls without ICDs. In patients with and without ICDs, no significant difference was evident in terms of perceived health status, psychological distress, sense of coherence, and health behaviors. A more threatening illness perception was seen in relation to ICDs among adults with CHD, and those with secondary vs primary prevention indications experienced a lower quality of life. However, PROs demonstrated marked geographic variability. ICD recipients (vs controls) from Switzerland, Argentina, Taiwan, and the United States, experienced a significantly lower overall sense of well-being, evaluated by a summary score that integrates many PROs.