Impact of transcatheter aortic valve durability on life expectancy in low-risk patients with severe aortic stenosis
Circulation Jul 31, 2020
Tam DY, Wijeysundera HC, Naimark D, et al. - Researchers used discrete event simulation modeling to determine how transcatheter aortic valve durability could impact life expectancy in low-risk patients with severe aortic stenosis, given that recent clinical trial findings demonstrated that transcatheter aortic valve replacement (TAVR) is noninferior and may be superior to surgical aortic valve replacement (SAVR) for death, stroke, and rehospitalization. The simulation models used in this study necessitate the durability of TAVR valves to be 70% shorter than that of surgical valves in order to cause decreased life expectancy in patients with demographics similar to those of recent trials. However, this threshold for TAVR valve durability was shown to be substantially higher in younger patients. As per the observations, there should be no impact of durability concerns on the initial treatment decision regarding TAVR vs SAVR in older low-risk patients in view of current evidence supporting TAVR valve durability. However, weighing valve durability against other patient factors such as life expectancy is mandatory in younger low-risk patients.
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