Levi A, et al. - Researchers determined the impact of family history of premature cardiovascular disease (FHpCVD) on the outcome of patients presenting with acute coronary syndrome (ACS). Based on the presence or absence of self-reported FHpCVD, all patients ≤ 65 years of age at admission who had an ACS event and were enrolled in the national ACSIS registry between 2000 and 2013 were divided into groups and assessed for 30-day MACE (defined as the composite of death, unstable angina pectoris, myocardial infarction, stroke, stent thrombosis and urgent revascularization) and its individual components. An evenly matched cohort of patients was created by applying nearest neighbor propensity score matching (PSM). Based on the presence/absence of FHpCVD, they found no differences in short and intermediate-term outcomes. However, better long-term survival was observed in patients with FHpCVD.