Pagnesi M, Kim WK, Conradi L, et al. - Researchers assessed the use as well as the influence of pre-implantation balloon aortic valvuloplasty (pre-BAV) prior to transcatheter aortic valve implantation (TAVI) with Acurate neo. A total of 1,263 patients who underwent transfemoral TAVI with Acurate neo were retrospectively enrolled in the NEOPRO Registry. For 1,262 patients (99.9%), data on pre-BAV was available. This analysis involved 1,262 patients who had TAVI with (n = 1,051) or without predilatation (n = 211). Pre-discharge moderate-to-severe paravalvular aortic regurgitation (PAR II+), 30-day new permanent pacemaker implantation, and 30-day all-cause mortality or stroke were assessed as primary endpoints. Experts noted that pre-BAV and no pre-BAV groups exhibited similarity in terms of primary endpoints. Between groups, the requirement for postdilatation and other procedural results were comparable. Findings are suggestive of the feasibility as well as safety of transfemoral Acurate neo implantation without predilatation, particularly in patients exhibiting milder degrees of aortic valve and left ventricular outflow tract calcification.