Katagiri Y, et al. - In the SYNTAX II study, a multicenter, all-comers, open-label, single arm study, researchers investigated whether minimal stent area (MSA) evaluated by post-procedural intravascular ultrasound influences clinical outcomes following contemporary PCI in patients with three-vessel disease. They analyzed 819 lesions with post-procedural MSA from 367 patients and found an independent correlation of larger post-procedural MSA with a lower rate of target lesion revascularization at 2 years. Smaller post-procedural MSA, creatinine clearance, history of previous stroke, chronic total occlusion, and lesion SYNTAX Score could independently predict TLR, as seen in multivariate analysis.