Kaneko H, et al. - Researchers analyzed data from 717 patients with severe aortic stenosis (AS) and heart failure (HF) undergoing transcatheter aortic valve implantation (TAVI) to investigate the role of the N-terminal pro-B-type natriuretic peptide (NT-proBNP) response and to identify the determinants of the NT-proBNP nonresponse among these patients. NT-proBNP nonresponse was more frequent in association with female sex and prevalence of diabetes mellitus, chronic kidney disease, atrial fibrillation, and history of coronary artery revascularization. NT-proBNP nonresponders displayed higher permanent pacemaker implantation rate. Lower survival rates were evident among NT-proBNP nonresponders with baseline NT-proBNP level > 7500 pg/smL. Findings thus suggested NT-proBNP response as important for predicting long-term survival after TAVI. The aforementioned determinants, particularly permanent pacemaker implantation, should therefore be considered as risk factors for NT-proBNP nonresponse.