Chkhartishvili N, et al. - Researchers sought to determine the predictors of mortality among people living with HIV (PLWH) with hepatitis C co-infection in Georgia. In this retrospective nationwide cohort study, adult PLWH diagnosed between 2004–2016 were followed up until 31 December 2017. A total of 22,322 person-years (PY) of follow-up was undertaken in 4,560 persons, including 2,058 (45.1%, 10,676 PY) anti-hepatitis C virus + (HCV+) patients. Death was reported for 954 persons, including 615 anti-HCV+ patients, during the median follow-up of 4.1 years. Persons with HCV vs HIV monoinfection had higher overall mortality (5.76/100 PY vs 2.91/100 PY). As per observations, AIDS remained the leading cause of death prior to and after 2011. A significant decline in mortality, including due to liver-related causes, was observed in correlation with wide availability of ART and anti-HCV therapy. Excess AIDS-related mortality could be reduced with improving earlier diagnosis among people living with HIV/HCV co-infection.