Lemor A, et al. - In patients admitted with Takotsubo syndrome (TTS), whether in-hospital outcomes varied based on gender was investigated in a population from the National Inpatient Sample database with patients admitted with a principal diagnosis of TTS from 2006 to 2014 using the ICD9-CM code 429.83. Researchers identified 39,662 admissions with TTS, 91.7% were female and 8.3% were male with mean age of 66.5 and 61.6 years, respectively. Potential confounders were adjusted via multivariate regression models. Findings revealed a progressive increase in the incidence of TTS from 2006 to 2014. Hypertension, hypothyroidism, and depression were more likely to be seen in female patients; males were more likely to use tobacco, or have known coronary artery disease. An almost 4-fold higher probability of in-hospital mortality was observed among males vs females (3.7% vs 1.1%). TTS was more common in females but males more commonly developed certain complications, including cardiogenic shock, ventricular fibrillation/tachycardia, and acute kidney injury, and had higher morbidity and mortality.