Yagi M, et al. - In this retrospective review, experts studied the impact of frailty and comorbidities on postoperative health-related quality of life (HRQoL) and complication rates. For this investigation, they reviewed the results of consecutive elective spine surgeries for 156 adult spinal deformities (ASDs), 152 degenerative spondylolisthesis (DS), or 173 lumbar spinal canal stenosis (LSCS), with a follow-up of at least 2 years. As compared to the other populations, ASDs were frailer and had more comorbidities. Findings revealed that postsurgical outcomes and complication rates deteriorated in ASDs as frailty and Charlson Comorbidity Index (CCI) increased, whereas surgery produced favorable outcomes and acceptable complication rates in DS and LSCS irrespective of frailty and CCI. Results of this study suggested that careful patient selection and treatment of comorbidities prior to surgery might decrease complications and make for better outcomes for the surgical treatment of ASD.