Venturelli PM, et al. - Via this study of 9,485 adult patients with a clinical diagnosis of acute ischemic stroke (AIS or intracerebral hemorrhage), researchers assessed the relationship of evidence-based processes of care for AIS and clinical outcome of patients who engaged in the HEADPOST (Head Positioning in Acute Stroke Trial; a multicenter cluster crossover trial of lying flat vs sitting up, head positioning in acute stroke). Reperfusion therapy in eligible patients, acute stroke unit care, antihypertensive, antiplatelet, statin, and anticoagulation for atrial fibrillation, dysphagia assessment, and physiotherapist review were eight included AIS processes of care. An association of implementation of all methods of care in eligible patients (or “defect-free” care) with better results and survival was observed. Defect-free stroke care was also significantly correlated with an outstanding outcome (modified Rankin Scale score 0–1). Still, no hospital component was an independent predictor of the outcome. Only 1,445 (15%) of qualified patients with AIS underwent all processes of care, with significant regional variations in overall and individual rates. In AIS, the utilization of evidence-based care was related to improved clinical outcomes.