Shamoun F, et al. - In heart failure with reduced ejection fraction (HFrEF), whether the extent of left ventricular (LV) eccentric structural remodeling is directly related to clinical event responses to cardiac resynchronization therapy (CRT) was investigated by retrospectively analyzing the data from the COMPANION (Comparison of Medical Therapy, Pacing and Defibrillation in Heart Failure) trial. Using 2-dimensional echocardiography, pre-randomization measurements of left ventricular internal dimensions at end diastole indexed by body surface area (LVEDDI) were obtained. An attenuation in all-cause mortality (ACM) with CRT with only pacing capability or CRT with an implantable defibrillator treatment, as well as a more effective attenuation in ACM/heart-failure hospitalization with the combined CRT treatment groups, was observed in relation to larger vs smaller LVEDDIs.