Sweeney E, et al. - In the South of Ireland over a 13-year period, researchers examined how different Bacillus Calmette-Guerin (BCG) vaccination policies (neonatal vaccination [vaccinated Region-A], vaccination of children aged 10–12 years [vaccinated Region-B] and no vaccination [unvaccinated Region-C]) influence the incidence of tuberculosis (TB) disease. Through surveillance data, they identified 621 cases of TB. Based on the reported addresses, 510 of these could be connected to the study area. Based on BCG vaccination policy, TB incidence varied significantly by region in demographically similar populations. They noted higher incidence of TB disease in the unvaccinated population Region-C 132/100,000 vs vaccinated Region-A 56/100,000 and Region-B 44/100,000. These findings thereby confirm the effectiveness of BCG vaccination for primary prevention of TB disease.