Varshney A, et al. - In this retrospective analysis of consecutive patients who underwent transcatheter aortic valve replacement (TAVR) at a single academic center, researchers assessed the link between antithrombotic regimens and outcomes. Categorized antithrombotic regimens included single or dual antiplatelet therapy (AP), single antiplatelet plus anticoagulant (SAC), or triple therapy (TT). They obtained adjusted hazard ratios (HRs) with best subset variable selection methods using bootstrap resampling. Findings demonstrated that even after multivariate adjustment, a significantly higher risk of the composite outcome of death, myocardial infarction, stroke, or major bleeding was reported at 2-year follow-up in TAVR patients treated with TT or SAC vs AP.