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Impact of adjuvant lorazepam with granisetron on chemotherapy-induced nausea and vomiting in pediatric patients with acute lymphoblastic leukemia

Supportive Care in Cancer Feb 13, 2019

Ono A, et al. - Researchers assessed the effect of lorazepam with granisetron on chemotherapy-induced nausea and vomiting (CINV) in children with acute lymphoblastic leukemia (ALL) via reviewing the records of 71 consecutive patients with newly diagnosed ALL who received chemotherapy including vincristine, anthracycline, and systemic steroids between January 2011 and December 2016 in their hospital. Granisetron was provided to all patients as CINV prophylaxis. Outcomes suggested that providing lorazepam as adjuvant antiemetic had no beneficial effect on the prevention of CINV in children with ALL. Female gender and older age (> 5 years) were identified to be the significant risk factors for CIV.
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