Amador-Patarroyo MJ, et al. - In this observational, case-crossover study involving 80 patients (160 eyes), researchers sought to assess the quality of oral fluorescein angiography (FA) in relation to food intake. At the Shiley Eye Institute, information from patients undergoing routine oral FA for the retinal disease was gathered. The same patient's fasting and non-fasting images were registered, compared and analyzed by experienced retina experts for different image quality parameters and clinical significance. According to multivariate analysis, non-fasting patients with higher body mass index had the worst scores. During the pre-fasting exam, other clinical parameters like staining of drusen, staining of disciform scars or central and peripapillary atrophy were also significantly better. When compared with non-fasting oral FA, fasting oral FA provided significantly better quality images as well as faster optimal imaging times. By improving its overall quality, oral FA may be a useful adjunctive examination to optical coherence tomography (OCT) and OCT angiography in patients requiring FA studies but who have difficult access or refusing an invasive procedure.