Raafs A, Verdonschot J, Ferreira JP, et al. - This study was undertaken to investigate the gender-specificity of 252 protein biomarkers for new-onset heart failure (HF). Researchers used a matched case–control design in patients selected from cohorts within the HOMAGE consortium. They matched cases (new-onset HF, n = 562) and controls (n = 780) for cohort (PREDICTOR, HEALTH-ABC, & PROSPER), follow-up time (defined as time from entry to incident HF), and age. They further assessed targeted plasma proteins (n = 252) using Proximity Extension Assay technology from O-link. Despite clear differences in biomarkers at baseline, the majority of biomarkers correlated with incident HF did not significantly differ between women and men.