Rocca S, et al. - Researchers investigated if human immunodeficiency virus (HIV)-antibody repertoire could estimate the viral reservoir size. Further, they assessed the magnitude of HIV-antibody response as a predictor of time of antiretroviral therapy (ART) initiation. Assigning HIV Western blot (WB) kit and a WB score to each patient, they evaluated HIV-antibody responses to 10 different viral proteins. Based on the timing of ART initiation, patients were classified into 2 subgroups: early treated [ET], 0–24 weeks and late treated [LT], >24 weeks. ET patients showed reduced HIV-specific antibody responses and lower size of HIV-deoxyribonucleic acid (DNA) compared to the LT patients. Outcomes suggest the possible potential of Western blot score in estimating HIV-DNA size and the timing of ART initiation in long-term virally suppressed children. This suggests the utility of this rapid, inexpensive, and easily reproducible tool in identifying potential candidates for HIV remission studies.