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Human chorionic gonadotrophin hormone for treatment of congenital undescended testis: Anatomical barriers to its success

Journal of Pediatric Surgery Mar 16, 2019

Elsherbeny MS, et al. - Researchers aimed to determine the anatomical abnormalities in the congenital undescended testis that might contribute to the failure of hormonal therapy with human chorionic gonadotrophin. They studied 75 boys (between 6 months and 4 years [mean 1.6 years, median 2 years]) with congenital undescended testes who received treatment with human chorionic gonadotrophin, in Pediatric Surgery Department, Faculty of medicine, Ain Shams University during the period from January 2014 to December 2015. Observations revealed low success rates with human chorionic gonadotrophin hormone in these patients. Complete descent was noted in only 7 testes (7%) (2 bilateral and 3 unilateral) that were initially high scrotal in position, partial descent was observed for 8 testes (8%) (2 bilateral and 4 unilateral), 6 of these were inguinal that became high scrotal and 2 were impalpable which became peeping. No response to the hormonal treatment was observed in the remaining 85 (85%) which may be due to anatomical abnormalities in the congenital undescended testis.
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