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Hospitalization and mortality among pediatric cancer survivors: A population-based study

Cancer Causes and Control Sep 11, 2018

Mueller BA, et al. - Researchers used 1982-2014 Washington State population-based data to compare long-term (up to 27 years) outcomes, including hospitalization and/or death (including cause-specific), among childhood cancer survivors. They examined all 5+ year childhood cancer survivors who were < 20 years at diagnosis (n=3,152) and a sample of comparison children within birth cohorts, evaluated by cancer type and child/family characteristics. For the rarely-studied outcomes of long-term fracture and injury, they found increased risk. In addition, findings corroborated that survivors were at increased risks of selected other conditions. Increased hazard ratios and 95% confidence intervals for hospitalization and any-cause death were observed, as well as for all cause-specific outcomes examined, most notably cancer-, hematological-, nervous system-, and circulatory- related outcomes. Females and subjects receiving radiation were more often hospitalized, with moderate differences by urban/rural birth residence and race/ethnicity. A variance was seen in cause-specific outcomes by cancer type.

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