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Hospital admission for neurologic disorders among five-year survivors of non-central nervous system tumors in childhood: A cohort study within the Adult Life after Childhood Cancer in Scandinavia (ALiCCS) study

International Journal of Cancer Apr 18, 2019

Kenborg L, et al. - Among 15,967 five-year survivors of non-central nervous system (CNS) childhood cancer diagnosed in Denmark, Iceland, Finland, and Sweden from 1943-2008 and 151,118 matched participants for comparison, researchers examined the lifetime risk for neurologic disorders. Survivors of neuroblastoma and leukemia had the highest risks, with curiously high risks for hospitalization for paralytic syndromes and hydrocephalus seen in survivors of neuroblastoma, and additional high risks for dementia, encephalopathy, and neuropathy seen in survivors of leukemia. The most common diagnosis was epilepsy. Outcomes revealed high risk for neurologic disorders among survivors of non-CNS childhood cancer. This risk was especially high within the first 10 years following diagnosis. Therefore, they recommend performing intensive follow-up to identify those who require close management.

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