Heravi AS, Etzkorn LH, Urbanek JK, et al. - Given a greater risk for sudden arrhythmic death is seen in people living with human immunodeficiency virus (HIV+) vs HIV-uninfected (HIV–) people, and a possible contributor to this risk is HIV-associated abnormal cardiac repolarization, so, researchers examined if there exists a link between HIV serostatus and ventricular repolarization lability, utilizing the QT variability index (QTVI), defined as a log measure of QT-interval variance indexed to heart rate variance. Overall 1,123 men, including 589 HIV+ and 534 HIV–, were examined from MACS, employing the ZioXT ambulatory electrocardiography patch. Findings revealed greater beat-to-beat variability in QT interval (QTVI) among HIV+ men vs HIV– men, specifically in the setting of HIV viremia and increased inflammation. In HIV+ men, higher QTVI implied ventricular repolarization lability, which could raise susceptibility to arrhythmias, whereas a component of autonomic dysfunction was suggested by lower heart rate variability.