Einarsen E, Cramariuc D, Bahlmann E, et al. - Among 1,530 asymptomatic patients with presumably mild-moderate aortic valve stenosis (AS), normal ejection fraction, and without known diabetes or cardiovascular disease, this inquiry was performed to determine the link of increased acceleration time (AT)/ejection time (ET) ratio on prognosis. Patients were included in the SEAS study (Simvastatin Ezetimibe Aortic Stenosis). Based on the optimal AT/ET ratio threshold to predict cardiovascular death as well as heart failure hospitalization, patients were categorized. A significant correlation of higher AT/ET ratio with lower systolic blood pressure, lower left ventricular ejection fraction, lower stress-corrected midwall shortening, low flow, and with higher left ventricular mass and higher peak aortic jet velocity was identified. For predicting incident cardiovascular mortality and heart failure hospitalization in the entire study population, AT/ET ratio ≥ 0.32 afforded the optimal cutoff. In this study, increased cardiovascular morbidity and mortality were reported in relation to higher AT/ET ratio in asymptomatic nonsevere AS and low-gradient severe AS.