Xu R, et al. - In this retrospective study involving 8,229 Chinese aged adults, aged 65 to 99 years, researchers intended to determine if there is an association between C-reactive protein (CRP) and carotid artery plaque (CAP). High-sensitivity CRP (hs-CRP) concentrations were measured at baseline (2013) in patients who were categorized into three groups: low risk (<1.0 mg/L), intermediate risk (1.0–3.0 mg/L), and high risk (≥3.0 mg/L). They utilized a logistic regression model for the cross-sectional connection between CRP concentration and CAP status and proportional hazardous Cox model for prospective analyses. The adjusted odds ratios for CAP was 1.66 in the intermediate-risk group and 1.72 in the high-risk group vs the low-risk group, following adjustment for potential confounders. During a 5-year follow-up, 512 incident CAP cases were identified. In Chinese aged adults, high hs-CRP concentration was linked to a high risk of developing CAP.