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High prevalence of non-dipping patterns among Black Africans with uncontrolled hypertension: A secondary analysis of the CREOLE trial

BMC Cardiovascular Disorders May 28, 2021

Ingabire PM, Ojji DB, Rayner B, et al. - Researchers undertook this secondary analysis of the CREOLE Study (Comparison of Three Combination Therapies in Lowering Blood Pressure in Black Africans: a randomized, single blind, three-group trial in 6 Sub-Saharan African countries), to estimate the prevalence as well as the factors related to non-dipping pattern and ascertain the impact of 6 months of three antihypertensive regimens on the dipping pattern in Black African patients with hypertension. Participants were 721 in total, with ages between 30 and 79 years, experiencing uncontrolled hypertension. The estimated prevalence of the non-dipping pattern was 78% (564 of 721). Serum sodium > 140 mmol/l, a higher office systolic blood pressure (BP) and a lower office diastolic BP were revealed as the factors that were independently related to non-dipping. Dipping status at 6 months was not altered by treatment allocation. Overall, findings revealed that Black Africans with uncontrolled hypertension had a high prevalence of non-dipping. Considering ambulatory blood pressure monitoring more routinely in Black Africans with uncontrolled hypertension is recommended, if resources allow, in order to aid personalise therapy.

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