Inoue M, Sawada N, Goto A, et al. - In this cohort study of 19,106 Japanese men and women who were followed from 1993-2013, experts assessed the relationship between a high-negative anti-Hp IgG titer and the long-term risk of gastric cancer in the Japan Public Health Center-based Prospective Study (JPHC Study) Cohort II. Results imply that those with a high-negative anti-Hp IgG titer and moderate and severe AG were at heightened long-term risk of gastric cancer. Thus, in cases with high-negative anti-Hp IgG titer, the development of moderate or severe AG is proposed to improve the risk of gastric cancer.