Chernyavskiy P, et al. - Since knowing the geographic heterogeneity of colorectal cancer incidence is important for allocating resources for intervention, researchers used the 2000–2014 Surveillance, Epidemiology, and End Results (SEER) database to estimate relative risk (RR) and age-adjusted annual percent change (Net Drifts) simultaneously for 612 counties by using a hierarchical model, separately for colon and rectum cancer, stratified by age group (20–54 vs. 55–84). Also, the correlates of RR and Net Drift with various county-level features were also analyzed. They found increased incidence rates of colon and rectum cancer at ages 20–54 and decreased rates at ages 55–84 in all SEER counties. A tendency to have a higher prevalence of obesity and diabetes and to be of a lower socioeconomic status was reported for counties with high RR and unfavorable Net Drift; this was observed for both cancer types. Geographically widespread increases in colorectal cancer incidence was seen in the younger age group, although significant heterogeneity was seen in temporal trends and risk both within and between states. There was a correlation between these geographic patterns and different county-level features, depending on cancer type and age group.