Li Y, et al. - In this study including 2,033 women between 18 and 91 years of age from the Twins UK cohort, researchers assessed age-related increase in central pulse pressure relative to arterial stiffening and ventricular ejection dynamics. By Doppler sonography and carotid tonometry, they measured aortic flow and central blood pressure, respectively. They performed comparisons between measured values of central pulse pressure and values predicted from aortic pulse wave velocity and ventricular ejection features. According to the findings, an increase in arterial stiffening and changed pattern of ventricular ejection were the key drivers of age-related change in central pulse wave morphology.